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KMID : 0895820220320030131
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Journal of Oriental Rehabilitation Medicine
2022 Volume.32 No. 3 p.131 ~ p.140
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Hepatic and Renal Safety of Concurrent Use of Conventional and Herbal Medications for Musculoskeletal Disorders: A Retrospective Observational Study
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Kim Se-Yoon
Kim Hyoung-Seok
Kim Hyung-Suk
Kang Do-Young
Ko Jun-Hyuk
Kim Jong-Yeon
Kim Koh-Woon
Kim Bo-Hyung
Cho Jae-Heung
Song Mi-Yeon
Chung Won-Seok
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Abstract
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Objectives This study aimed to investigate whether the concurrent use of conventional and herbal medications affects liver and kidney function, by examining blood test data.
Methods We retrospectively reviewed the electronic medical records of 590 inpatients with musculoskeletal diseases between 2013 and 2017. We investigated cases of drug-induced liver injury (DILI) according to the Roussel Uclaf Causality Assessment Method criteria and cases of drug-induced kidney injury (DIKI) based on the Kidney Disease Improving Global Outcomes definition.
Results One case (0.17%) of DILI and one case (0.17%) of DIKI were identified. Significant improvements in serum laboratory data were observed after the concurrent use of both types of medications (p<0.05). The kappa coefficients ranged from 0.26 to 0.72, indicating that the values after the concurrent use of conventional and herbal medications showed a fair similarity to the baseline values of the patients. The linear regression test showed that female sex and high body mass index (BMI) were risk factors for an increase in the serum blood levels of liver function parameters.
Conclusions The concurrent use of conventional and herbal medications for musculoskeletal disorders is relatively safe; however, clinicians should exercise caution when prescribing these medications to female patients and patients with a high BMI because of their potential effect on hepatic function.
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KEYWORD
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Drug-induced kidney injury, Chemical and drug induced liver injury, Herbal medication, Musculoskeletal disorder, Retrospective studies
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